This issue of Physician Assistant Clinics, guest edited by Fred Wu and Dr. Michael E. Winters, is devoted to Emergency Medicine. Articles in this outstanding issue include: Anaphylaxis; Back Pain Emergencies; Lethal Rashes; Pregnancy Disasters in the First Trimester; Current Concepts in the Evaluation of the Febrile Child; Skin and Soft Tissue Infections; Pitfalls in Wound Management; Ocular Emergencies; Deadly Drug Ingestions; Low Risk Chest Pain; Headache Mistakes You Don’t Want to Make; Asymptomatic Hypertension in the Emergency Department; Orthopedic Pearls and Pitfalls; and Antibiotic Stewardship: Choosing Wisely.