This is a comprehensive review text of more than 500 questions with complete answers for the Physician Assistant National Certifying Examination (PANCE). It contains 17 main sections of questions and answers by subject with special bibliographies for each chapter covering diseases and disorders of the central nervous system, eye, ear and nose and mouth and throat, respiratory system, circulatory system, digestive system, behavioral and emotional disorders, musculoskeletal system, skin and subcutaneous tissue, endocrine and nutrition and metabolism, kidneys and urinary tract, male and female reproductive systems, pregnancy and childbirth and neonates, and more.