This issue of Physician Assistant Clinics, guest edited by Kim Zuber, PA-C and Jane S. Davis, CRNP, DNP, is devoted to Critical Care Medicine. This comprehensive issue includes the following articles: The PA in Critical Care Medicine; Pharmacology in Critical Care: When, What, and How Much; Bacteria and Viruses: The Bogeymen in the ICU; The Heart of the Matter: CHF, Cardiac Arrest, Cardiac Shock, ST Elevation MI’s, Cardiac Arrhythmias, Hemodynamics, and Hypertensive Crisis; The Heart of the Matter: Cardiac Surgery, Cardiovascular Surgery Complications, Mechanical Devices, and ECMO; Breathe In, Breathe Out: Respiratory Considerations in the ICU; When the Kidney goes Rogue: Acute Kidney Infection in the ICU; Bridge Over Troubled Water: Fluid in the ICU; The Gland Plan: Endocrine Emergencies in Critical Care; Slip, Slipping Away: The Brain in the ICU; Gastroenterology, Hepatology, and Nutrition in the ICU; Special Intensive Care: The SICU; The Sick Child: the PICU; Crash: Trauma Management; and Saying Goodbye: Discussing End of Life Issues with the Critically Ill Patient and Family. CME credits are also available to subscribers of this series.